Prolonged and demand-based release of drugs is critical to achieving an optimal therapeutic effect in addition to selective delivery and effective localisation in the target site. Therefore, the nanoparticles whose drug release profile can be controlled by in vivo cues such as a change in pH, redox, enzyme activity, temperature, etc., and external stimuli like the addition of exogenous molecule, light and magnetic field are preferred for several applications.
The Thurecht Group is interested in the development and in vivo assessment of biologically responsive polymers for the imaging of a biological process, as well as to give mechanistic insight with respect to the interaction of the nanomaterial with the biological environments it encounters.
List of Projects
Targeted stealth nanoparticles: Design, synthesis and understanding it’s in vivo response by balancing the stealth versus targeting components